This course provides a strong foundation in the basic and applied science of cancer biology. The content is delivered in lectures, tutorials and practical laboratories. The following main topics are covered: DNA damage and repair; mechanisms of cell proliferation, cell death, differentiation, metabolic reprogramming and cell stress response; tumour hypoxia and radiation biology; genomics, bioinformatics and epigenetics; selected mechanisms of cancer development (inherited, viral and hormonal causes); basics of cancer immunology and metastasis; principles of an integrated cancer diagnosis.
There are four 3-hour interactive laboratories that provide an opportunity to practice selected laboratory methods and reflect on their use in cancer research. Laboratories address the following research areas: 1. Mechanism of apoptosis; 2. Radiation-induced cell killing; 3.Application of bioinformatic approaches to characterise cancer mechanisms; 4. Integrated characterisation of leukaemia pathology.
There is also an online assignment on colorectal cancer - its pathology, detection and treatment.
The following lecturers teach in this course: Dr Maggie Kalev (course director), Dr Rachelle Singleton (course coordinator), Assoc Prof Michael Hay, Prof Nuala Helsby, Dr Dean Singleton, Assoc Prof Cherie Blenkiron, Dr Annette Lasham, Dr Ana Ramachandran, Dr Jo Perry, Dr Kimiora Henare, Dr Petr Tomek and Dr Nicky Lawrence.
The course provides a strong foundation for progressing to postgraduate studies and research in cancer. The Department of Molecular Medicine & Pathology and Auckland Cancer Society Research Centre offer multiple options in this field. For example, MedSci 714 and MedSci 713 provide a focused look at aspects of cancer biology and treatment targets, respectively.